"Awakening" from schizophrenia: intramolecular polypharmacy and the atypical antipsychotics.

380 J Clin Psychiatry 58:9, September 1997 © Coyright 997 Phsicians Poraduate Pess, nc. ne pesonal opy ay be pinted social functioning, which far too many patients experience. The new atypical antipsychotics have attempted to put together the right blend of pharmacologic mechanisms and eliminate the misfits in order to compose an even better symphony than the one played by clozapine, so the new atypical antipsychotics are each creating their own unique ensembles of mechanisms. There are more than a half dozen atypical antipsychotics, including three already marketed in the United States, namely clozapine, riss the ideal antipsychotic a soloist or a member of a large ensemble? The earliest Issue: Clever combinations of pharmacologic mechanisms may enhance the efficacy of antipsychotic drugs and alter the course of schizophrenia.